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1. (WO2017041102) ACOUSTIC BLOOD SEPARATION PROCESSES AND DEVICES
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Pub. No.: WO/2017/041102 International Application No.: PCT/US2016/050415
Publication Date: 09.03.2017 International Filing Date: 06.09.2016
IPC:
A61M 1/36 (2006.01) ,B01D 21/28 (2006.01) ,B06B 1/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
21
Separation of suspended solid particles from liquids by sedimentation
28
Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
B PERFORMING OPERATIONS; TRANSPORTING
06
GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
B
GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
1
Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency
02
making use of electrical energy
06
operating with piezo-electric effect or with electrostriction
Applicants:
FLODESIGN SONICS, INC. [US/US]; 380 Main Street Wilbraham, Massachusetts 01095, US
Inventors:
GILMANSHIN, Rudolf; US
LIPKENS, Bart; US
DUTRA, Brian; US
KENNEDY, Daniel; US
Agent:
KLEIN, Richard M.; US
Priority Data:
62/214,56704.09.2015US
62/371,82907.08.2016US
Title (EN) ACOUSTIC BLOOD SEPARATION PROCESSES AND DEVICES
(FR) PROCÉDÉS ET DISPOSITIFS DE SÉPARATION ACOUSTIQUE DU SANG
Abstract:
(EN) Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
(FR) La présente invention concerne des dispositifs acoustophorétiques. Les dispositifs comprennent une chambre d'écoulement, un transducteur à ultrasons, un réflecteur, une entrée, une sortie de filtrat, une sortie de concentré, et éventuellement un piège de collecte de lipide. Le transducteur à ultrasons et le réflecteur créent une onde stationnaire acoustique multi-dimensionnelle dans la chambre d'écoulement qui piège et sépare les globules rouges et/ou les lipides du sang. Les globules rouges concentrés peuvent être récupérés par l'intermédiaire de la sortie de concentré, les lipides peut être récupérés par l'intermédiaire du piège de collecte de lipide, et le sang restant peut être récupéré par l'intermédiaire de la sortie de filtrat. L'invention concerne également des procédés de séparation de composants du sang (p. ex. globules rouges, lipides, plaquettes, globules blancs) du sang. Les globules rouges peuvent subir un lavage avec un solvant afin d'éliminer les impuretés non désirées. Des agents cryoprotecteurs peuvent être ajoutés ou retirés du sang.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)