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1. (WO2017041051) INTRACELLULAR DELIVERY OF BIOMOLECULES TO CELLS COMPRISING A CELL WALL

Pub. No.:    WO/2017/041051    International Application No.:    PCT/US2016/050288
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: B82Y 5/00
C12M 1/42
C12N 15/87
G01N 1/30
G01N 15/14
C12M 3/06
C12N 15/82
Applicants: SQZ BIOTECHNOLOGIES COMPANY
Inventors: SHAREI, Armon, R.
BERNSTEIN, Howard
GILBERT, Jonathan, B.
Title: INTRACELLULAR DELIVERY OF BIOMOLECULES TO CELLS COMPRISING A CELL WALL
Abstract:
The present disclosure pertains to methods for delivering a compound into a cell comprising a cell wall, including passing a cell suspension through a constriction, wherein said constriction deforms the cell comprising a cell wall, thereby causing a perturbation of the cell such that the compound enters the cell, wherein said cell suspension is contacted with the compound.