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1. (WO2017041043) SELECTION OF PATIENTS FOR COMBINATION THERAPY

Pub. No.:    WO/2017/041043    International Application No.:    PCT/US2016/050274
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: G01N 33/574
G01N 33/487
C07C 223/06
C12N 5/0786
Applicants: SYNDAX PHARMACEUTICALS, INC.
Inventors: ORDENTLICH, Peter
Title: SELECTION OF PATIENTS FOR COMBINATION THERAPY
Abstract:
Described herein are methods for selecting cancer patients for treatment with a combination therapy comprising entinostat and a second therapeutic agent. In particular, methods are provided for the examination of a non-cancer cell type, myeloid-derived suppressor cells, e.g., those which are CD14-positive and HLA-DR-(lo/negative), as a therapeutic indicator in the setting of entinostat combination therapies.