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1. (WO2017041041) THREE-DIMENSIONAL DIFFERENTIATION OF EPIBLAST SPHEROIDS TO KIDNEY ORGANOIDS MODELS STAGE-SPECIFIC EPITHELIAL PHYSIOLOGY, MORPHOGENESIS, AND DISEASE
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Pub. No.: WO/2017/041041 International Application No.: PCT/US2016/050271
Publication Date: 09.03.2017 International Filing Date: 02.09.2016
IPC:
A61K 35/22 (2015.01) ,A61K 35/44 (2015.01) ,A61K 47/42 (2017.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
22
Urine; Urinary system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
44
Eyes; Vessels; Umbilical cord
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
Applicants:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street Boston, Massachusetts 02115, US
Inventors:
FREEDMAN, Benjamin S.; US
BONVENTRE, Joseph V.; US
Agent:
RESNICK, David S.; US
EISENSTEIN, Ronald, I.; US
FITZERALD, Mark J.; US
BENN, Susanna C.; US
BRAICH, Ravinderjit S.; US
KARTTUNEN CONTARINO, Leena H.; US
CROSBY, David F.; US
HUFF, Shayne, Y.; US
MILLS, Tari W.; US
PTASHKA, Teresa A.; US
SUMMERFORD, Candace M.; US
KLING, Nicole D.; US
CHEN, Stephen, W.; US
Priority Data:
62/213,74003.09.2015US
Title (EN) THREE-DIMENSIONAL DIFFERENTIATION OF EPIBLAST SPHEROIDS TO KIDNEY ORGANOIDS MODELS STAGE-SPECIFIC EPITHELIAL PHYSIOLOGY, MORPHOGENESIS, AND DISEASE
(FR) DIFFÉRENCIATION EN TROIS DIMENSIONS DES SPHÉROÏDES DE L'ÉPIBLASTE EN FONCTION DE LA PHYSIOLOGIE, DE LA MORPHOGENÈSE ET DE LA MALADIE ÉPITHÉLIALE SPÉCIFIQUE AU STADE DE MODÈLES D'ORGANOÏDES RÉNAUX
Abstract:
(EN) Human pluripotent stem cells (hPSCs) have dual value as microphysiological laboratory models and regenerative therapeutics. hPSCs are epithelial cells, but the extent to which hPSCs and descendant epithelia can reconstitute lineage-specific functions remains poorly understood. Here the Inventors show that hPSCs in three-dimensional cultures and their differentiated descendants can functionally recapitulate tissue-specific epithelial morphogenesis, physiology, and disease.
(FR) La présente invention concerne des cellules souches pluripotentes humaines (hPSC) ayant une double valeur comme modèles de laboratoire de microphysiologie et agents thérapeutiques en médecine régénérative. Les hPSC sont des cellules épithéliales, mais la mesure dans laquelle les hPSC et l'épithélium descendant peuvent reconstituer des fonctions spécifiques à la lignée reste mal comprise. Les inventeurs de la présente invention montrent que des hPSC dans des cultures en trois dimensions et leurs descendants différenciés peuvent fonctionnellement récapituler la morphogenèse, la physiologie et la maladie épithéliale spécifique au tissu.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)