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1. (WO2017041032) PROTOCELLS TO TREAT MICROBIAL INFECTION AND FOR SYNERGISTIC DELIVERY
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Pub. No.: WO/2017/041032 International Application No.: PCT/US2016/050259
Publication Date: 09.03.2017 International Filing Date: 02.09.2016
IPC:
A61K 9/51 (2006.01) ,B82Y 5/00 (2011.01) ,B82Y 40/00 (2011.01) ,C12Q 1/04 (2006.01) ,A61K 31/7088 (2006.01) ,C07K 19/00 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
40
Manufacture or treatment of nano-structures
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
BRINKER, C. Jeffrey [US/US]; US
CARNES, Eric. C. [US/US]; US
ASHLEY, Carlee Erin [US/US]; US
NEGRETE, Oscar [US/US]; US
WILKINSON, Dan C. [US/US]; US
WILKINSON, Brian S. [US/US]; US
PADILLA, David Patrick [US/US]; US
Inventors:
BRINKER, C. Jeffrey; US
CARNES, Eric. C.; US
ASHLEY, Carlee Erin; US
NEGRETE, Oscar; US
WILKINSON, Dan C.; US
WILKINSON, Brian S.; US
PADILLA, David Patrick; US
Agent:
PERDOK, Monique M.; US
Priority Data:
62/214,31604.09.2015US
62/214,38104.09.2015US
62/214,40604.09.2015US
Title (EN) PROTOCELLS TO TREAT MICROBIAL INFECTION AND FOR SYNERGISTIC DELIVERY
(FR) PROTOCELLULES POUR TRAITER LES INFECTIONS MICROBIENNES ET POUR UNE DÉLIVRANCE SYNERGIQUE
Abstract:
(EN) The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections caused by a Hendra virus and Nipah virus (NiV). The present disclosure relates to protocells that are useful in the treatment of bacterial infections, including antibiotic-resistant bacterial infections. The protocells are coated with a lipid bi- or multilayer comprising at least one moiety that targets a viral cellular receptor and at least one moiety that ruptures a virally-infected cell membrane. The present disclosure further relates to novel mesoporous metal oxide nanoparticles and related protocells that are useful in the treatment and/or prevention of a wide variety of disorders, including a cancer or a bacterial or viral infection. Such nanoparticles and protocells can be functionalized to allow for synergistic loading of a wide variety of active ingredients.
(FR) La présente invention concerne des protocellules utilisables dans le traitement et la prévention d'infections virales, y compris, mais sans y être limité, d'infections provoquées par le virus Hendra et le virus Nipah (NiV, pour "Nipah virus"). La présente invention concerne des protocellules utilisables dans le traitement d'infections bactériennes, y compris des infections bactériennes résistantes aux antibiotiques. Les protocellules sont revêtues d'une couche bi- ou multi-lipidique comprenant au moins une partie qui cible un récepteur cellulaire viral et au moins une partie qui rompt la membrane des cellules infectées par un virus. La présente invention concerne également de nouvelles nanoparticules d'oxyde métallique mésoporeuses et des protocellules associées qui sont utilisables dans le traitement et/ou la prévention d'une grande diversité de troubles, y compris des cancers ou des infections bactériennes ou virales. De telles nanoparticules et protocellules peuvent être fonctionnalisées pour permettre le chargement synergique d'une grande diversité de principes actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)