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1. (WO2017041017) TRANSFORMATIONS OF MESO-LACTIDE

Pub. No.:    WO/2017/041017    International Application No.:    PCT/US2016/050235
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: C08G 63/08
Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors: CHEN, Eugene Y.
ZHU, Jian-Bo
Title: TRANSFORMATIONS OF MESO-LACTIDE
Abstract:
B/N Lewis pairs have been discovered to catalyze rapid epimerization of meso-lactide (LA) or LA diastereomers quantitatively into rac-LA. The obtained rac-LA can be kinetically polymerized into poly(L-lactide) and optically resolved D-LA, with a high stereoselectivity factor kL/kD of 53 and an ee value of 91% at 50.6% monomer conversion, by a bifunctional chiral catalyst. The epimerization and enantioselective polymerization can be coupled into a one-pot process for transforming meso-LA directly into poly(L-lactide) and D-LA.