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1. (WO2017041004) COMPOSITIONS AND METHODS FOR MODULATING T-CELL MEDIATED IMMUNE RESPONSE
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Pub. No.: WO/2017/041004 International Application No.: PCT/US2016/050219
Publication Date: 09.03.2017 International Filing Date: 02.09.2016
IPC:
C07K 16/28 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US/US]; 1800 Grant Street 8th Floor Denver, Colorado 80203, US
Inventors:
ZHU, Yuwen; US
EDIL, Barish H.; US
SCHULICK, Richard D.; US
PANICCIA, Alessandro; US
KOENIG, Michelle; US
SCHULICK, Alexander C.; US
Agent:
KARNAKIS, Jennifer A.; US
Priority Data:
62/213,30502.09.2015US
62/370,51203.08.2016US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING T-CELL MEDIATED IMMUNE RESPONSE
(FR) COMPOSITIONS ET PROCÉDÉS DE MODULATION D'UNE RÉPONSE IMMUNITAIRE À LYMPHOCYTES T
Abstract:
(EN) The present disclosure relates to compositions and methods for modulating T-cell mediated immune response in a subject in need thereof. The method includes administering to the subject an effective amount of a CD112R protein, a fusion polypeptide, a complex including CD112R and a second protein, or an anti-CD112R antibody of the present disclosure.
(FR) La présente invention concerne des compositions et des procédés pour moduler une réponse immunitaire médiée par les lymphocytes T chez un sujet en ayant besoin. Le procédé comprend l'administration au sujet d'une quantité efficace d'une protéine CD112R, un polypeptide de fusion, un complexe comprenant CD112R et une deuxième protéine, ou un anticorps anti-CD112R de la présente invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)