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1. (WO2017040986) METHODS FOR TREATING HEART FAILURE USING GLUCAGON RECEPTOR ANTAGONISTIC ANTIBODIES

Pub. No.:    WO/2017/040986    International Application No.:    PCT/US2016/050183
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: A61K 38/26
A61K 39/395
A61K 45/06
A61P 9/10
Applicants: REMD BIOTHERAPEUTICS, INC.
Inventors: YAN, Hai
Title: METHODS FOR TREATING HEART FAILURE USING GLUCAGON RECEPTOR ANTAGONISTIC ANTIBODIES
Abstract:
The present disclosure relates to methods for treating or preventing heart failure using a glucagon receptor blocking agent. In various embodiments, the present disclosure relates to methods for treating or preventing heart failure (e.g., post-myocardial infarction heart failure), diabetic cardiomyopathy heart failure), and lateral ventricular (LV) remodeling, using antigen binding and antagonizing proteins, e.g., fully human antibodies, that specifically bind to and antagonize the function of the human glucagon receptor.