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1. (WO2017040960) PROGRAMMED CELL DEATH 1 (PD-1 ) INHIBITOR THERAPY FOR PATIENTS WITH PD-1 -EXPRESSING CANCERS

Pub. No.:    WO/2017/040960    International Application No.:    PCT/US2016/050148
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: A61K 39/395
A61P 35/00
G01N 33/53
G01N 33/574
G01N 33/68
C07K 16/28
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventors: SCHATTON, Tobias
KLEFFEL, Sonja
POSCH, Christian
Title: PROGRAMMED CELL DEATH 1 (PD-1 ) INHIBITOR THERAPY FOR PATIENTS WITH PD-1 -EXPRESSING CANCERS
Abstract:
Described herein are biomarkers comprising mTOR, PI3K/AKT, and MAPK/ERK signaling pathway members as well as cap-dependent translation initiation factors that enable monitoring and predicting responses to PD-1 pathway blockade in patients afflicted with cancers characterized by PD-1 expression.