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1. (WO2017040953) COMPOSITIONS AND METHODS RELATING TO RAD6 INHIBITION
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Pub. No.: WO/2017/040953 International Application No.: PCT/US2016/050141
Publication Date: 09.03.2017 International Filing Date: 02.09.2016
IPC:
A61K 31/53 (2006.01)
[IPC code unknown for A61K 31/53]
Applicants:
WAYNE STATE UNIVERSITY [US/US]; 5057 Woodward Ave. Suite 6400 Detroit, MI 48202, US
Inventors:
SHEKHAR, Malathy; US
MAO, Guangzhao; US
ZHANG, Yanhua; US
Agent:
STAPLE, D., Julie, K.; US
STAPLE, Julie, K.; US
CITKOWSKI, Ronald, W.; US
CHOI, Yongsok; US
CHAU, John; US
Priority Data:
62/213,24802.09.2015US
Title (EN) COMPOSITIONS AND METHODS RELATING TO RAD6 INHIBITION
(FR) COMPOSITIONS ET MÉTHODES RELATIVES À L'INHIBITION DU RAD6
Abstract:
(EN) Pharmaceutical compositions, methods of treatment of proliferative diseases and commercial packages are provided according to aspects of the present invention which relate to a first therapeutic agent coupled to a nanoparticle, wherein the first therapeutic agent is SMI#8 or SMI#9, a pharmaceutically acceptable salt, ester, amide, stereoisomer, hydrate, or derivative of either thereof. According to particular aspects, the SMI#8 or SMI#9 is conjugated to gold nanoparticles.
(FR) L'invention concerne des compositions pharmaceutiques, des méthodes de traitement de maladies prolifératives et des emballages commerciaux; selon des aspects de la présente invention, ces compositions comprennent un premier agent thérapeutique couplé à une nanoparticule, le premier agent thérapeutique étant SMI#8 ou SMI#9, un sel pharmaceutiquement acceptable, un ester, un amide, un stéréoisomère, un hydrate, ou un dérivé de l'un ou l'autre de ceux-ci. Selon des aspects particuliers, SMI # 8 ou SMI # 9 est conjugué à des nanoparticules d'or.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)