Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017040945) IMMUNE CELL COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/040945 International Application No.: PCT/US2016/050128
Publication Date: 09.03.2017 International Filing Date: 02.09.2016
IPC:
A61K 39/00 (2006.01) ,A61K 35/17 (2015.01) ,C07K 14/705 (2006.01) ,C07K 14/725 (2006.01) ,C12N 5/0783 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
[IPC code unknown for A61K 35/17]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
Applicants:
MEMORIAL SLOAN KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, NY 10065, US
Inventors:
ADUSUMILLI, Prasad, S.; US
SADELAIN, Michel; US
Agent:
ANTLER, Adriane, M.; US
GEORGE, Nikolaos, C.; US
FRIEBEL, Thomas, E.; US
INSOGNA, Anthony, M.; US
ROWAN, Thomas, G.; US
Priority Data:
62/214,80904.09.2015US
Title (EN) IMMUNE CELL COMPOSITIONS AND METHODS OF USE
(FR) COMPOSITIONS À BASE DE CELLULES IMMUNITAIRES ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Disclosed herein are cells that are immune cells or precursor cells thereof, which cells recombinantly express a chimeric antigen receptor (CAR), and a dominant negative form of an inhibitor of a cell-mediated immune response of the immune cell, wherein the CAR binds to a cancer antigen. Also disclosed herein are T cells that recognize and are sensitized to a cancer antigen, which T cells recombinantly express a dominant negative form of an inhibitor of a T cell-mediated immune response. Additionally provided are methods of using such cells to treat cancer in a subject in need thereof.
(FR) La présente invention concerne des cellules qui sont des cellules immunitaires ou des cellules précurseurs de celles-ci, lesquelles cellules expriment de manière recombinante un récepteur antigénique chimérique (CAR), et une forme négative dominante d'un inhibiteur d'une réponse immunitaire à médiation cellulaire de la cellule immunitaire, dans lesquelles le récepteur CAR se lie à un antigène du cancer. L'invention concerne également des lymphocytes T qui reconnaissent un antigène du cancer et y sont sensibilisés, lesquels lymphocytes T expriment de manière recombinante une forme négative dominante d'un inhibiteur d'une réponse immunitaire à médiation par les lymphocytes T. L'invention concerne également des procédés d'utilisation desdites cellules pour traiter le cancer chez un sujet qui en a besoin.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)