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1. (WO2017040928) STABILIZED GLUCAGON SOLUTIONS
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Pub. No.: WO/2017/040928 International Application No.: PCT/US2016/050110
Publication Date: 09.03.2017 International Filing Date: 02.09.2016
IPC:
A61K 9/08 (2006.01) ,A61K 38/26 (2006.01) ,A61P 3/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
26
Glucagons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
Applicants:
LATITUDE PHARMACEUTICALS, INC. [US/US]; 6364 Ferris Square San Diego, California 92121, US
Inventors:
CHEN, Hailiang; US
CHEN, Andrew Xian; US
ORIDA, Norman Keith; US
Agent:
SNYDER, Joseph R.; US
HAO, Joe C.; US
PRESLEY, Andrew D.; US
TRIMBLE, Alexander R.; US
Priority Data:
62/214,83104.09.2015US
Title (EN) STABILIZED GLUCAGON SOLUTIONS
(FR) SOLUTIONS STABILISÉES DE GLUCAGON
Abstract:
(EN) This invention relates to ready-to-use and safe solution compositions of glucagon suitable for administration by manual injection or by an insulin pump or other injection device to treat hypoglycemia. Said compositions comprise glucagon, an acid, anti-gelling polyol, a stabilizing-salt, viscosity reducer and an antioxidant, have a final pH between about 2 and 5, and is gel-free, chemically-stable, and pump-able.
(FR) La présente invention concerne des compositions prêtes à l'emploi et sûres de solutions de glucagon appropriées pour une administration par injection manuelle ou par une pompe à insuline ou un autre dispositif d'injection pour traiter l'hypoglycémie. Lesdites compositions comprennent du glucagon, un acide, un polyol anti-gélifiant, un sel de stabilisation, un agent réducteur de viscosité et un antioxydant, ont un pH final compris entre environ 2 et 5, et sont exemptes de gel, chimiquement stables, et pouvant être pompées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)