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1. (WO2017040916) MODULATION OF GPR124 FOR REDUCTION OF PATHOLOGICAL FIBROSIS

Pub. No.:    WO/2017/040916    International Application No.:    PCT/US2016/050095
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: A61K 31/7105
A61K 39/395
A61K 31/711
A61K 31/713
A61P 13/12
A61P 1/16
Applicants: EVOTEC AG
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventors: ANDAG, Uwe
HUMPHREYS, Benjamin, D.
Title: MODULATION OF GPR124 FOR REDUCTION OF PATHOLOGICAL FIBROSIS
Abstract:
Agents and methods for treating, reducing or ameliorating pathological fibrosis and disease or disorders caused by or associated with excessive deposition of fibrous tissue, and methods of identifying suitable agents. Preferred agents modulate the level and/or activity of GPR124.