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1. (WO2017040906) DI-FUNCTIONALIZED HYALURONIC ACID DERIVATIVES AND HYDROGELS THEREOF

Pub. No.:    WO/2017/040906    International Application No.:    PCT/US2016/050074
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: A61K 8/73
A61K 31/728
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors: SMITH CALLAHAN, Laura, A.
LIM, Hyun, Ju
Title: DI-FUNCTIONALIZED HYALURONIC ACID DERIVATIVES AND HYDROGELS THEREOF
Abstract:
Provided herein are di-functionalized hyaluronic acids, such as molecules including (or that have been functionalized at) a thiol and azide side chain. Also, provided herein are hydrogels of these di-functionalized hyaluronic acids and methods of using these compounds to promote cell (e.g., neuronal cell) growth and development. In some aspects, the present disclosure also provides methods of treating injuries, including brain injuries such as stroke through the use of hydrogels of the compounds described herein and stem cells.