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1. (WO2017040879) THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY

Pub. No.:    WO/2017/040879    International Application No.:    PCT/US2016/050029
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: C07D 471/04
C07D 513/04
A61K 31/519
A61P 25/16
A61P 25/24
A61P 25/28
A61P 27/06
A61P 35/02
A61P 3/10
A61P 13/12
Applicants: LYSOSOMAL THERAPEUTICS INC.
Inventors: SKERLJ, Renato, T.
GOOD, Andrew, C.
ZHENG, Jianbin
LANSBURY, Peter, T.
Title: THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY
Abstract:
The invention provides heterobicyclic pyrimidinone compounds such as thiazolo[3,2-a]pyrimidinone compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary heterobicyclic pyrimidinone compounds described herein include 5-oxo- 2,3-dihydro-5H-hiazolo[3,2-a]pyrimidine-6-carboxarnide compounds.