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1. (WO2017040815) RECOMBINANT VECTORS COMPRISING 2A PEPTIDE

Pub. No.:    WO/2017/040815    International Application No.:    PCT/US2016/049947
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: C12N 15/867
C12N 7/01
A61P 35/00
Applicants: TOCAGEN INC.
Inventors: JOLLY, Douglas, J.
LIN, Amy, H.
HOFACRE, Andrew
HOGAN, Daniel J.
OSTERTAG, Derek G.
Title: RECOMBINANT VECTORS COMPRISING 2A PEPTIDE
Abstract:
This disclosure provides modified recombinant retroviruses comprisings containing a 2A-peptide or peptide-like coding sequence operably linked to a heterologous polynucleotide. The disclosure further relates to cells and vector expressing or comprising such vectors and methods of using such modified vectors in the treatment of disease and disorders.