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1. (WO2017040805) ION-ACTIVATED PHOTOLABILE COMPOUNDS
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Pub. No.: WO/2017/040805 International Application No.: PCT/US2016/049937
Publication Date: 09.03.2017 International Filing Date: 01.09.2016
IPC:
A61N 5/06 (2006.01) ,C07C 229/40 (2006.01) ,G01N 21/64 (2006.01)
[IPC code unknown for A61N 5/06][IPC code unknown for C07C 229/40][IPC code unknown for G01N 21/64]
Applicants:
HOWARD HUGHES MEDICAL INSTITUTE [US/US]; 4000 Jones Bridge Road Chevy Chase, MD 20815, US
Inventors:
SCHREITER, Eric, R.; US
GRIMM, Jonathan, B,; US
HECKMAN, Laurel, M.; US
LAVIS, Luke, D.; US
Agent:
DECKER, Mandy, W.; US
HAYNE, James, R.; US
NAGLE, David, W.; US
HAEBERLIN, Jeffrey, A.; US
WRIGHT, Terry, L.; US
Priority Data:
62/212,97601.09.2015US
Title (EN) ION-ACTIVATED PHOTOLABILE COMPOUNDS
(FR) COMPOSÉS PHOTOLABILES ACTIVÉS PAR IONS
Abstract:
(EN) The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; R1 is selected from H, halogen, alkyl, and acyl; each R2 is independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and R3 is selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), PO3H2, and SO3H, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO2, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR2, PO3H2, and/or SO3H. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds.
(FR) La présente invention concerne des composés photolabiles activés par analytes. Les composés comprennent la formule : Z comprend une molécule pouvant être masquée; L est choisi parmi une liaison, C, C(O), O, alkyle, (O)alkyle et alcoxy; R1 est choisi parmi H, halogène, alkyle et acyle; chaque R2 est choisi indépendamment parmi H, alkyle, aryle et acyle, et est éventuellement substitué par un ou plusieurs hétéro-atomes choisis indépendamment parmi COOH et COO(alkyle); et R3 est choisi parmi H, alkyle, aryle, halogène, CN, OH, O(alkyle), O(aryle), SH, S(alkyle), S(aryle), amine, CHO, COOH, COO(alkyle), COO(aryle), PO3H2 et SO3H, et est éventuellement substitué par un ou plusieurs hétéro-atomes choisis indépendamment parmi N, O, et S, halogène, OH, O(alkyle), O(aryle), SH, S(alkyle), S(aryle), amine, NO2, CHO, COO, COOH, COO(alkyle), COO(aryle), C(O)NR2, PO3H2 et/ou SO3H. L'invention concerne également des procédés de détection de calcium et de traitement d'un sujet avec les composés photolabiles activés par analytes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)