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1. (WO2017040762) METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS

Pub. No.:    WO/2017/040762    International Application No.:    PCT/US2016/049869
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: A01N 63/02
A01P 1/00
A61K 38/16
A61P 31/04
G01N 21/64
G01N 33/53
Applicants: THE SCRIPPS RESEARCH INSTITUTE
Inventors: WOLAN, Dennis, W.
OWENSBY, Anna
Title: METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS
Abstract:
This invention provides purified and recombinantly-produced bacterial lipoprotein signal peptidase (Lsp) enzymes and in vitro assays for monitoring Lsp catalytic activities. Also provided in the invention are screening methods for identifying novel antibiotic agents and their therapeutic applications for treating bacterial infections. Further provided in the invention are specific Lsp inhibitory compounds which can be used as bactericidal agents in treating diseases caused by bacterial infections.