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1. (WO2017040719) BACTERIA ENGINEERED TO TREAT DISORDERS IN WHICH OXALATE IS DETRIMENTAL

Pub. No.:    WO/2017/040719    International Application No.:    PCT/US2016/049781
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: A61K 35/74
C12N 1/00
Applicants: SYNLOGIC, INC.
Inventors: ISABELLA, Vincent
FALB, Dean
ANDERSON, Cami, Leigh
MILLER, Paul
MILLET, Yves
KOTULA, Jonathan
Title: BACTERIA ENGINEERED TO TREAT DISORDERS IN WHICH OXALATE IS DETRIMENTAL
Abstract:
The present invention provides recombinant bacterial cells comprising at least one heterologous gene encoding at least one oxalate catabolism enzyme. In another aspect, the recombinant bacterial cells further comprise at least one heterologous gene encoding an importer of oxalate. The invention further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders in which oxalate is detrimental, such as hyperoxaluria, using the pharmaceutical compositions of the invention.