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1. (WO2017040686) IDENTIFICATION OF CIRCULATING CANCER ASSOCIATED FIBROBLASTS
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Pub. No.: WO/2017/040686 International Application No.: PCT/US2016/049730
Publication Date: 09.03.2017 International Filing Date: 31.08.2016
IPC:
A61M 1/34 (2006.01) ,B01D 61/14 (2006.01) ,G01N 33/574 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34
Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
61
Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
14
Ultrafiltration; Microfiltration
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
UNIVERSITY OF MIAMI [US/US]; Office of Technology Transfer 1951 NW 7th Avenue-3rd Floor-suite 310 Miami, FL 33136, US
Inventors:
LIPPMAN, Marc, E.; US
AO, Zheng; US
SHAH, Sanket, H.; US
DATAR, Ram, H.; US
EL-ASHRY, Dorraya; US
Agent:
ALLIKIAN, Michael, J.; US
STEPHENS, Paul, B.; US
Priority Data:
62/212,83001.09.2015US
Title (EN) IDENTIFICATION OF CIRCULATING CANCER ASSOCIATED FIBROBLASTS
(FR) IDENTIFICATION DE FIBROBLASTES CIRCULANTS ASSOCIÉS AU CANCER
Abstract:
(EN) The present disclosure relates to the use of cancer associated fibroblasts (CAFs) as a diagnostic or prognostic tool to identify metastatic cancer and/or for evaluating a patient's response to cancer therapy. The disclosure also provides methods for directly targeting CAFs for anticancer therapy.
(FR) La présente invention concerne l'utilisation de fibroblastes circulants associés au cancer (CAF) en tant qu'outil de diagnostic ou de pronostic pour identifier un cancer métastatique et/ou pour évaluer la réponse d'un patient à une cancérothérapie. L'invention concerne également des procédés pour cibler directement des CAF pour un traitement anti-cancéreux.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)