Search International and National Patent Collections

1. (WO2017040653) HBED PRODRUGS AND USE THEREOF

Pub. No.:    WO/2017/040653    International Application No.:    PCT/US2016/049689
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: A61K 31/198
A61K 31/69
Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPPORATED
Inventors: THIELE, Nikki, A.
Title: HBED PRODRUGS AND USE THEREOF
Abstract:
The present invention provides N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED) prodrugs of Formula (I), (II), and (III), and pharmaceutically acceptable salts, tautomers, stereoisomers, solvates, hydrates, and polymorphs for treatment or prevention of diseases that are associated with oxidative stress and/or excess metal (e.g. iron). The present invention further provides HBED prodrugs of Formula (I), (II), and (III), and pharmaceutically acceptable salts, tautomers, stereoisomers, solvates, hydrates, and polymorphs for the treatment and/or prevenation of macular degeneration. The provided HBED prodrugs may have improved oral availability and/or brain penentration compared to HBED.