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1. (WO2017040629) HONEY ELUTING CRYOGEL FOR TISSUE ENGINEERING

Pub. No.:    WO/2017/040629    International Application No.:    PCT/US2016/049655
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: A61L 27/52
A61L 27/56
A61K 35/644
Applicants: SAINT LOUIS UNIVERSITY
Inventors: SELL, Scott A.
HIXON, Katherine R.
JAIN, Era
KADAKIA, Parin
Title: HONEY ELUTING CRYOGEL FOR TISSUE ENGINEERING
Abstract:
Tissue engineering structures with biologically favorable structural and chemical properties are disclosed. More particularly, the present disclosure is directed to tissue engineered structures having a cryogel scaffold and honey. The tissue engineered structures having a cryogel scaffold and honey can further include at least one biomolecule. The tissue engineered structures can be used to promote cellular chemotaxis, enhance cell proliferation, enhance extracellular matrix production, increase angiogenesis, and provide antimicrobial activity. The nature of the tissue engineered structures provides a template for cellular infiltration and guide tissue regeneration. The tissue engineered structures can be used in the treatment of dermal wounds (burns, chronic wounds, etc.) or as a tissue engineering scaffold in a wide range of applications.