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1. (WO2017040510) COLORIMETRIC LABELING AND DETECTION METHODS AND COMPOSITIONS
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Pub. No.: WO/2017/040510 International Application No.: PCT/US2016/049467
Publication Date: 09.03.2017 International Filing Date: 30.08.2016
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
LIFE TECHNOLOGIES CORPORATION [US/US]; 5823 Newton Drive Carlsbad, California 92008, US
Inventors:
CLARKE, Scott; US
GEE, Kyle; US
FINNESSY, Carmen; US
Priority Data:
62/212,37631.08.2015US
Title (EN) COLORIMETRIC LABELING AND DETECTION METHODS AND COMPOSITIONS
(FR) PROCÉDÉS ET COMPOSITIONS DE MARQUAGE ET DE DÉTECTION COLORIMÉTRIQUE
Abstract:
(EN) The present disclosure provides methods, compositions and kits for measuring cellular nascent nucleic acid synthesis by colorimetric labeling of nucleic acid. The nucleic acid synthesis can be measured as cell proliferation, DNA or RNA synthesis, gene expression or apoptosis. Additionally, these methods may be used to screen compounds for their effect on cellular proliferation by treating cells or an organism with the test compound simultaneous to or before treatment with a competitive nucleoside analog.
(FR) La présente divulgation concerne des procédés, des compositions et des kits pour mesurer la synthèse d'un acide nucléique cellulaire naissant par marquage colorimétrique de l'acide nucléique. La synthèse de l'acide nucléique peut être mesurée sous forme de prolifération cellulaire, synthèse d'ADN ou d'ARN, expression génique ou apoptose. De plus, ces procédés peuvent être utilisés pour identifier par criblage des composés ayant un effet sur la prolifération cellulaire par traitement des cellules ou d'un organisme avec le composé d'essai simultanément, ou avant traitement à l'aide d'un analogue de nucléoside compétitif.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)