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1. (WO2017040498) TECHNIQUES OF MASS SPECTROMETRY FOR ISOTOPOMER ANALYSIS AND RALATED SYSTEMS AND METHODS

Pub. No.:    WO/2017/040498    International Application No.:    PCT/US2016/049438
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Aug 31 01:59:59 CEST 2016
IPC: G01N 33/58
Applicants: YALE UNIVERSITY
Inventors: MASON, Graeme
ALVES, Tiago
KIBBEY, Richard
Title: TECHNIQUES OF MASS SPECTROMETRY FOR ISOTOPOMER ANALYSIS AND RALATED SYSTEMS AND METHODS
Abstract:
According to some aspects, a spectrometer is provided, the spectrometer configured to receive molecules of a plurality of metabolites including one or more molecules of a first metabolite, filter the received molecules to retain molecules of the first metabolite including a plurality of different mass isotopomers of the first metabolite, fragment molecules of a first mass isotopomer of the retained molecules to produce a first plurality of daughter ions, measure abundances of the first plurality of daughter ions as a function of daughter ion mass, fragment molecules of a second mass isotopomer, different from the first mass isotopomer, of the retained molecules to produce a second plurality of daughter ions, and measure abundances of the second plurality of daughter ions as a function of daughter ion mass.