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1. (WO2017040459) IMPROVED SOLUBILITY FOR TARGET COMPOUNDS
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Pub. No.: WO/2017/040459 International Application No.: PCT/US2016/049365
Publication Date: 09.03.2017 International Filing Date: 30.08.2016
IPC:
C07D 493/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
Applicants:
AUNOVA MEDCHEM LLC [US/US]; 211 Warren Street Newark, New Jersey 07103, US
Inventors:
SIDDURI, Achyutharao; US
Agent:
GEARHART, Richard; US
Priority Data:
15/250,33629.08.2016US
62/214,51904.09.2015US
Title (EN) IMPROVED SOLUBILITY FOR TARGET COMPOUNDS
(FR) SOLUBILITÉ AMÉLIORÉE POUR COMPOSÉS CIBLES
Abstract:
(EN) The present disclosure relates to compounds having an improved solubility thereby increasing their bioavailability, lower dosages, etc. The target compounds, may include but are not limited to, macrophage migration inhibitory factor (MIF) inhibitors, epidermal growth factor receptor (EGRF) inhibitors, kinase inhibitors and prodrugs of alpha4 beta1 and alpha4 beta7 integrin antagonists. An illustrative compound is shown below (Formula I):
(FR) La présente invention concerne des composés ayant une solubilité améliorée, en augmentant ainsi leur biodisponibilité, des doses plus faibles, etc. Les composés cibles peuvent comprendre, mais sans s'y limiter, des inhibiteurs de facteur d'inhibition de migration de macrophages (MIF), des inhibiteurs de récepteur de facteur de croissance épidermique (EGRF), des inhibiteurs de kinase et des promédicaments d'antagonistes d'intégrine alpha4 bêta1 et alpha4 bêta7. Un composé illustratif est représenté ci-dessous (Formule I) :
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)