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1. (WO2017040421) COMPOSITIONS AND METHODS FOR ACUTELY RAISING NITIC OXIDE LEVELS

Pub. No.:    WO/2017/040421    International Application No.:    PCT/US2016/049306
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Aug 30 01:59:59 CEST 2016
IPC: A61K 36/87
A61K 36/85
A61K 36/79
Applicants: NATURE'S SUNSHINE PRODUCTS, INC.
Inventors: TRIPP, Matthew L.
DAHLBERG, Clinton J.
BABISH, John G.
KAADIGE, Mohan
GAO, Wei
Title: COMPOSITIONS AND METHODS FOR ACUTELY RAISING NITIC OXIDE LEVELS
Abstract:
Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting meyloperoxidase activity.