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1. (WO2017040407) COMPOSITIONS AND METHODS FOR THE REDUCTION OR PREVENTION OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Pub. No.:    WO/2017/040407    International Application No.:    PCT/US2016/049272
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Aug 30 01:59:59 CEST 2016
IPC: A61K 9/12
A61K 31/05
A61K 31/192
A61K 31/198
A61K 31/235
A61K 31/4415
A61K 31/455
A61K 31/505
A61K 45/06
A61K 47/18
A61K 9/20
A61K 9/22
Applicants: NUSIRT SCIENCES, INC.
Inventors: ZEMEL, Michael
BRUCKBAUER, Antje
Title: COMPOSITIONS AND METHODS FOR THE REDUCTION OR PREVENTION OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Abstract:
Methods useful for sustaining a reduction of non-alcoholic steatohepatitis are provided herein. Such methods may comprise administering to a subject in need thereof a sirtuin pathway activator and/or PDE5 inhibitor alone or in combination with an amount of a branched amino acid in free amino acid form, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.