Search International and National Patent Collections

1. (WO2017040401) ANTIMICROBIAL AND ENZYME INHIBITORY ZINC OXIDE NANOPARTICLES

Pub. No.:    WO/2017/040401    International Application No.:    PCT/US2016/049250
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Aug 30 01:59:59 CEST 2016
IPC: A61L 2/23
A61L 2/238
A61L 2/232
A61K 9/51
A61K 33/30
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: VANEPPS, Jeremy Scott
KOTOV, Nicholas A.
Title: ANTIMICROBIAL AND ENZYME INHIBITORY ZINC OXIDE NANOPARTICLES
Abstract:
In certain aspects, the present disclosure provides an enzyme inhibitory nanoparticle. The nanoparticle may comprise zinc oxide. The nanoparticle exhibits substantially reversible enzyme inhibition in the presence of an enzyme. In certain aspects, the shape of the nanoparticle may be a nanopyramid or a nanoplate/nanodisc. In other aspects, the present disclosure provides an antimicrobial material comprising a layer-by-layer (LBL) coating comprising a plurality of nanoparticles comprising zinc oxide. Each nanoparticle exhibits antimicrobial activity in the presence of bacteria. LBL coatings of ZnO-NP reduced Staphylococcal biofilm burden by > 95%. The disclosure also provides methods of preparing an enzyme inhibitory or antimicrobial nanoparticles comprising zinc oxide.