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1. (WO2017040380) ENGINEERED ANTIBODY FC VARIANTS

Pub. No.:    WO/2017/040380    International Application No.:    PCT/US2016/049214
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Aug 30 01:59:59 CEST 2016
IPC: C07K 16/28
C07K 16/00
Applicants: RESEARCH DEVELOPMENT FOUNDATION
Inventors: GEORGIOU, George
LEE, Chang-han
Title: ENGINEERED ANTIBODY FC VARIANTS
Abstract:
In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for FcγRIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.γ