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1. (WO2017040344) CHIMERIC POLYPEPTIDE ASSEMBLY AND METHODS OF MAKING AND USING THE SAME

Pub. No.:    WO/2017/040344    International Application No.:    PCT/US2016/049137
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: A61K 38/16
A61K 38/17
A61K 38/24
Applicants: AMUNIX OPERATING INC.
Inventors: SCHELLENBERGER, Volker
YANG, Fan
THAYER, Desiree
SIM, Bee-cheng
WANG, Chia-wei
Title: CHIMERIC POLYPEPTIDE ASSEMBLY AND METHODS OF MAKING AND USING THE SAME
Abstract:
The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.