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1. (WO2017040332) QUANTIFYING NET AXONAL TRANSPORT IN MOTOR NEURON PATHOLOGIES
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Pub. No.: WO/2017/040332 International Application No.: PCT/US2016/049103
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
A61K 49/00 (2006.01) ,A61B 5/055 (2006.01) ,A61K 49/04 (2006.01) ,A61K 38/00 (2006.01)
[IPC code unknown for A61K 49][IPC code unknown for A61B 5/055][IPC code unknown for A61K 49/04][IPC code unknown for A61K 38]
Applicants:
UNIVERSITY OF MASSACHUSETTS [US/US]; One Beacon Street, 31st Floor Boston, Massachusetts 02108, US
Inventors:
BROWN, Robert H, Jr.; US
LEE, Justin Pin-Tsun; US
RUSCKOWSKI, Mary; US
Agent:
DEYOUNG, Janice Kugler; US
Priority Data:
62/211,52628.08.2015US
Title (EN) QUANTIFYING NET AXONAL TRANSPORT IN MOTOR NEURON PATHOLOGIES
(FR) QUANTIFICATION DU TRANSPORT AXONAL NET DANS DES PATHOLOGIES MOTONEURONALES
Abstract:
(EN) Methods of monitoring and diagnosing subjects with motor neuron pathology such as motor neuron disorders (including but not limited to amyotrophic lateral sclerosis (ALS)) and neuropathies, based on imaging of a labeled fragment of tetanus toxin, e.g., tetanus toxin C fragment.
(FR) L'invention concerne des méthodes de surveillance et de diagnostic pour des sujets présentant une pathologie motoneuronale telle que des troubles motoneuronaux (y compris, entre autres, la sclérose latérale amyotrophique (SLA)) et des neuropathies, ces méthodes étant basées sur l'imagerie d'un fragment de toxine tétanique marqué, tel que, par exemple, le fragment de toxine tétanique C.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)