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1. (WO2017040311) SYSTEMS AND METHODS FOR MATCHING ONCOLOGY SIGNATURES
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Pub. No.: WO/2017/040311 International Application No.: PCT/US2016/049063
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
A61K 35/13 (2015.01) ,C12N 5/09 (2010.01) ,G01N 33/574 (2006.01)
[IPC code unknown for A61K 35/13][IPC code unknown for C12N 5/09][IPC code unknown for G01N 33/574]
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 West 116th Street New York, NY 10027, US
Inventors:
CALIFANO, Andrea; US
ALVAREZ, Mariano, Javier; US
Agent:
RAGUSA, Paul A.; US
RAGUSA, Paul, A.; US
Priority Data:
62/211,56228.08.2015US
62/253,34210.11.2015US
Title (EN) SYSTEMS AND METHODS FOR MATCHING ONCOLOGY SIGNATURES
(FR) SYSTÈMES ET MÉTHODES DE MISE EN CORRESPONDANCE DE SIGNATURES ONCOLOGIQUES
Abstract:
(EN) Techniques to profile a disease or a disorder (e.g., a tumor) based on a protein activity signature are disclosed herein. An example method can include measuring quantitatively protein activity of a plurality of master regulator proteins in a sample from a disease or disorder; and profiling the tumor from the quantitative protein activity of the master regulator proteins. Also disclosed are methods of identifying a compound or compounds that treats diseases or disorders (e.g., inhibit tumor cell growth).
(FR) L'invention concerne des techniques permettant d'établir le profil d'une maladie ou d'un trouble (par exemple, une tumeur) en se basant sur la signature d'une activité protéique. Une méthode donnée à titre d'exemple peut consister à mesurer quantitativement l'activité protéique d'une pluralité de protéines de régulation maîtres dans un échantillon provenant d'une maladie ou d'un trouble; et à établir le profil de la tumeur à partir de l'activité protéique quantitative des protéines de régulation maîtres. L'invention concerne également des méthodes d'identification d'un composé ou de plusieurs composés qui traitent des maladies ou des troubles (par exemple, qui inhibent la croissance cellulaire d'une tumeur).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)