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1. (WO2017040309) PEPTIDE INHIBITORS OF TELOMERASE TRANSLOCATION AND THERAPEUTIC USES THEREOF
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Pub. No.: WO/2017/040309 International Application No.: PCT/US2016/049053
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
C07K 7/08 (2006.01) ,A61K 49/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
Applicants:
THE MEDICAL COLLEGE OF WISCONSIN, INC. [US/US]; 8701 Watertown Plank Road Milwaukee, WI 53226, US
Inventors:
EBBEN, Johnathan, D.; US
BEYER, Andreas, M.; US
Agent:
LEWIS, Jessica, L.; US
Priority Data:
62/211,52428.08.2015US
Title (EN) PEPTIDE INHIBITORS OF TELOMERASE TRANSLOCATION AND THERAPEUTIC USES THEREOF
(FR) INHIBITEURS PEPTIDIQUES DE TRANSLOCATION DE LA TÉLOMÉRASE ET LEURS UTILISATIONS THÉRAPEUTIQUES
Abstract:
(EN) This disclosure provides compositions and methods for treating or preventing cardiac or vascular toxicity in a subject receiving a chemotherapeutic agent, where the cardiac or vascular toxicity is associated with administration of the chemotherapeutic agent. Also provided are compositions and methods for treating or preventing endothelial dysfunction and for modulating endothelial function and oxidative stress.
(FR) La présente invention concerne des compositions et des procédés pour le traitement ou la prévention de la toxicité cardiaque ou vasculaire chez un sujet recevant un agent chimiothérapeutique, la toxicité cardiaque ou vasculaire étant associée à l'administration de l'agent chimiothérapeutique. L'invention concerne également des compositions et des procédés pour traiter ou prévenir un dysfonctionnement endothélial et pour moduler la fonction endothéliale et le stress oxydatif.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)