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1. (WO2017040304) MALT1 INHIBITORS AND USES THEREOF

Pub. No.:    WO/2017/040304    International Application No.:    PCT/US2016/049038
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: A61K 38/02
A61K 38/04
A61K 38/06
C07K 5/04
C07K 5/08
C07K 5/062
Applicants: CORNELL UNIVERSITY
DANA-FARBERE CANCER INSTITUTE, INC.
CHILDREN'S MEDICAL CENTER CORPORATION
Inventors: SCOTT, David, A.
HATCHER, John
CHENNAMADHAVUNI, Spandan
GABAS, Lorena, Fontan
QIAO, Qi
DU, Guangyan
MELNICK, Ari, M.
GRAY, Nathanael, S.
WU, Hao
Title: MALT1 INHIBITORS AND USES THEREOF
Abstract:
Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).