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1. (WO2017040258) ADULT STEM CELL COMPOSITIONS AND METHODS OF IDENTIFICATION AND ISOLATION

Pub. No.:    WO/2017/040258    International Application No.:    PCT/US2016/048919
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: A61K 35/12
A61K 35/545
C12N 5/074
C12N 5/0789
G01N 33/50
Applicants: CRAWFORD, Keith D.
VASIR, Baldev
GARVEY, John
Inventors: CRAWFORD, Keith D.
VASIR, Baldev
GARVEY, John
Title: ADULT STEM CELL COMPOSITIONS AND METHODS OF IDENTIFICATION AND ISOLATION
Abstract:
Methods, compositions and cells are provided that identify and isolate a population of adult non-embryonic progenitor cells having multilineage potential, physical diameters of about 2 ?m to about 8 ?m in size or about 4 ?m to about 6 ?m, and expressing at least one of the stem cell associated genes among Oct-4, KLF-4, Nanog, Sox-2, Rex-1, GDF-3 or Stella. Methods are also provided that identify and isolate populations, which are subsets or subpopulations of progenitor adult stem cells within the population of the adult stem cells which is a heterogeneous population, the methods including contacting the adult stem cells with a ligand specific for at least one of: CD99, tetraspan, ICAM4, full-length MUC1, and truncated MUC1 receptor, in which a presence of a surface protein on the cells that bind to the ligand identifies the population which is the subset of the differentiated progenitor adult stem cells.