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1. (WO2017040233) GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/040233 International Application No.: PCT/US2016/048830
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
C07D 471/04 (2006.01) ,A61K 31/4353 (2006.01) ,A61P 37/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
Applicants:
3M INNOVATIVE PROPERTIES COMPANY [US/US]; 3M Center Post Office Box 33427 Saint Paul, Minnesota 55133-3427, US
Inventors:
GRIESGRABER, George W.; US
Agent:
SILVERMAN, Eric E.; US
BLANK, Colene H.,; US
FLORCZAK, Yen Tong,; US
HARTS, Dean M.,; US
LEVINSON, Eric D.; US
MAKI, Eloise J.,; US
NOWAK, Sandra K.,; US
OLSON, Peter L.,; US
RHODES, Kevin H.; US
RINGSRED, Ted K.,; US
Priority Data:
62/211,89431.08.2015US
Title (EN) GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS
(FR) COMPOSÉS IMIDAZO[4,5-C] CYCLIQUES SUBSTITUÉS PAR GUANIDINE
Abstract:
(EN) Imidazo[4,5-c] ring compounds, (particularly imidzao[4,5-c]quinolines, 6,7,8,9- tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9- tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1- position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.
(FR) L'invention concerne des composés imidazo[4,5-c] cycliques (en particulier, des composés imidazo[4,5-c]quinoléines, 6,7,8,9-tétrahydroimidazo[4,5-c]quinoléines, imidazo[4,5-c]naphtyridines et 6,7,8,9-tétrahydroimidazo[4,5-c]naphtyridines) comprenant un substituant guanidine en position 1, des compositions pharmaceutiques contenant les composés et des procédés de préparation des composés. L'invention concerne également des procédés d'utilisation de ces composés en tant que modificateurs de réponse immunitaire, pour induire la biosynthèse de cytokines chez des animaux et dans le traitement de maladies incluant les maladies virales et néoplasiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)