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1. (WO2017040190) CRYSTALLINE FORMS OF (R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL-1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMIDE
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Pub. No.: WO/2017/040190 International Application No.: PCT/US2016/048616
Publication Date: 09.03.2017 International Filing Date: 25.08.2016
IPC:
C07D 401/14 (2006.01) ,A61K 31/4545 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for C07D 401/14][IPC code unknown for A61K 31/4545][IPC code unknown for A61P 35]
Applicants:
CONSTELLATION PHARMACEUTICALS, INC. [US/US]; 215 First Street, Suite 200 Cambridge, MA 02142, US
Inventors:
ALBRECHT, Brian, K.; US
ARRIGO, Alisha; US
GEHLING, Victor, S.; US
HACHÉ, Bruno, Patrice; US
HARMANGE, Jean-Christophe; US
LANE, Jonathan; US
CORSON, Donald; US
Agent:
DAVIS, Steven, G.; US
Priority Data:
62/211,38328.08.2015US
Title (EN) CRYSTALLINE FORMS OF (R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL-1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMIDE
(FR) FORMES CRISTALLINES DE (R)-N-((4-MÉTHOXY-6-MÉTHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)MÉTHYL)-2-MÉTHYL-1-(1-(1-(2,2,2-TRIFLUOROÉTHYL)PIPÉRIDIN-4-YL)ÉTHYL)-1H-INDOLE-3-CARBOXAMIDE
Abstract:
(EN) The present disclosure relates to a crystalline Forms A, B, and C of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders. Formula (I)
(FR) La présente invention concerne des formes cristallines A, B et C de (R)-N-((4-méthoxy-6-méthyl-2-oxo-1,2-dihydropyridin-3-yl)méthyl)-2-méthyl-1-(1-(1-(2,2,2-trifluoroéthyl)pipéridin-4-yl)éthyl)-1H-indole-3-carboxamide, chacune d'elles pouvant servir de modulateur de l'activité de méthyl-enzymes de modification d'histone. La présente invention concerne également des compositions pharmaceutiquement acceptables comportant les formes cristallines, et des méthodes d'utilisation desdites compositions dans le traitement de divers troubles. Formule (I)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)