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1. (WO2017040122) SYNTHETIC TISSUE CONTROLS AND SYNTHETIC TISSUE MICROARRAY CONTROLS

Pub. No.:    WO/2017/040122    International Application No.:    PCT/US2016/048217
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Aug 24 01:59:59 CEST 2016
IPC: G01N 33/50
G01N 1/30
G01N 33/48
G01N 33/53
Applicants: SLMP, LLC
Inventors: IMAM, Syed, Ashraf
REES, Mark, Lee
Title: SYNTHETIC TISSUE CONTROLS AND SYNTHETIC TISSUE MICROARRAY CONTROLS
Abstract:
The disclosed embodiments include methods to form STC and STMC for use in determining presence of cancer, and methods to detect presence of cancer. In one embodiment, A portion of a STC is stained. The STC includes normal cells and cancer cells of a type of cancer co-cultured based on at least one cell culturing factors. The at least one co-culture factors includes a type of the cancer cells being cultured, a ratio of the cancer cells to the normal cells being co-cultured, seeding density of the normal cells and the cancer cells being co-cultured, a type of cell growth supplement used to facilitate culturing the cells, and a concentration of the cell growth supplement used to facilitate co-culturing the cells. The stained portion is observed to determine presence of one or more biomarker types that indicate presence of cancer.