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1. (WO2017040078) PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/040078    International Application No.:    PCT/US2016/047946
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Aug 23 01:59:59 CEST 2016
IPC: C12N 15/113
A61K 31/713
Applicants: ALNYLAM PHARMACEUTICALS, INC.
Inventors: HINKLE, Gregory
Title: PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Abstract:
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the programmed cell death 1 ligand 1 (PD-Ll) gene, and methods of using such RNAi agents to inhibit expression of a PD-Ll gene and methods of treating subjects having a PD-Ll -associated disorder.