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1. (WO2017039778) OPIOID RECEPTOR MODULATORS AND USE THEREOF

Pub. No.:    WO/2017/039778    International Application No.:    PCT/US2016/037500
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Jun 16 01:59:59 CEST 2016
IPC: G01N 33/50
A61K 31/421
A61K 31/426
A61K 45/06
Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA
NATIONAL HEALTH RESEARCH INSTITUTES
Inventors: UENG, Shu-hua
YEH, Shiu-hwa
LOH, Horace
CHAO, Yu-sheng
Title: OPIOID RECEPTOR MODULATORS AND USE THEREOF
Abstract:
Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.