The present invention is directed to a sustained-release pharmaceutical composition comprising vinpocetine as active principle. The pharmacokinetics of the pharmaceutical composition is also disclosed. Disclosed composition is directed to the treatment of central nervous system diseases such as epilepsy and refractory epilepsy. In one embodiment, the present invention provides a vinpocetine composition for treatment of epilepsy. In another embodiment, the present invention provides a method of treatment of epilepsy comprising administering a pharmaceutical composition comprising vinpocetine to a patient.