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1. (WO2017039537) NOVEL FORMS OF APREMILAST AND THE PROCESS OF MAKING THE SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/039537 International Application No.: PCT/SG2016/050413
Publication Date: 09.03.2017 International Filing Date: 25.08.2016
IPC:
C07D 209/48 (2006.01) ,A61K 31/4035 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
48
with oxygen atoms in positions 1 and 3, e.g. phthalimide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
4035
Isoindoles, e.g. phthalimide
Applicants:
SCINOPHARM TAIWAN, LTD.; No. 1, Nan-Ke 8th Road Southern Taiwan Science Park, Shan-Hua Tainan, 74144, TW
SCINOPHARM SINGAPORE PTE, LTD. [SG/SG]; 50, Raffles Place #06-00 Singapore Land Tower Singapore 048623, SG (SG)
Inventors:
FANG, Hsiao-Ping; TW
LO, Wei-Shuo; TW
WANG, Kuan Hsun; TW
LIN, Yu-Sheng; TW
HU, Tsung-Cheng; TW
HUANG, Yuanchang; TW
Agent:
MATTEUCCI, Gianfranco; SG
Priority Data:
62/211,28028.08.2015US
62/279,14715.01.2016US
Title (EN) NOVEL FORMS OF APREMILAST AND THE PROCESS OF MAKING THE SAME
(FR) NOUVELLES FORMES D'APRÉMILAST ET LEUR PROCÉDÉ DE FABRICATION
Abstract:
(EN) The present invention provides novel crystalline forms of apremilast hemitoluene solvate, apremilast hydrate, and apremilast anhydrate and an amorphous form of apremilast, and processes for the preparation of these forms.
(FR) La présente invention concerne de nouvelles formes cristallines de solvate hémi-toluène d'aprémilast, d'hydrate d'aprémilast et d'anhydrate d'aprémilast, et une forme amorphe d'aprémilast, ainsi que des procédés pour la préparation de ces formes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)