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1. (WO2017039435) MEANS AND METHODS FOR SUSTAINED OXYGEN RELEASE IN SITU

Pub. No.:    WO/2017/039435    International Application No.:    PCT/NL2016/050595
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: A61L 27/18
A61L 27/54
A61K 9/50
Applicants: RIJKSUNIVERSITEIT GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
Inventors: BULSTRA, Sjoerd Klaas
STEG, Hilde
VELDHUIZEN, Albert Gerrit
KUIJER, Roelof
Title: MEANS AND METHODS FOR SUSTAINED OXYGEN RELEASE IN SITU
Abstract:
The invention relates to the field of tissue engineering and cell-based therapy. More in particular, it relates to an oxygen-releasing biomaterial that can enhance and support cell survival in vivo. Provided is an oxygen-delivering microsphere based on a biocompatible polymer, the microsphere comprising an agent capable of generating oxygen in situ encapsulated in a polymer matrix comprising poly (1,3-trimethylene carbonate) (PTMC). Also provided is an implantable device, like a scaffold for tissue engineering, comprising a plurality of oxygen-delivering microparticles according to the invention.