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1. (WO2017039383) FUSION POLYPEPTIDE IN WHICH ANTI-INFLAMMATORY POLYPEPTIDE AND FERRITIN MONOMER FRAGMENT ARE BOUND AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

Pub. No.:    WO/2017/039383    International Application No.:    PCT/KR2016/009845
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: C07K 19/00
C07K 14/79
C07K 14/47
C07K 14/54
A61K 38/16
A61K 38/17
Applicants: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
경북대학교 산학협력단
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
한국과학기술연구원
Inventors: BAE, Jong-Sup
배종섭
KIM, In-San
김인산
LEE, Won Hwa
이원화
SEO, Jun Young
서준영
KIM, So Youn
김소연
Title: FUSION POLYPEPTIDE IN WHICH ANTI-INFLAMMATORY POLYPEPTIDE AND FERRITIN MONOMER FRAGMENT ARE BOUND AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT
Abstract:
The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases. As in the above, the fusion polypeptide, which has an amino acid sequence represented by SEQ ID NO: 1 and in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a fragment of a human-derived ferritin monomer, can fuse two types of anti-inflammatory polypeptides, acting through different mechanisms, into a nano cage and administer the same, and thus the fusion polypeptide can exhibit an excellent effect in the treatment of inflammatory diseases including sepsis.