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1. (WO2017039382) HUMAN-DERIVED FERRITIN MONOMER FRAGMENT AND FUSION POLYPEPTIDE USING SAME

Pub. No.:    WO/2017/039382    International Application No.:    PCT/KR2016/009844
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: C07K 14/79
A61K 38/16
A61K 49/00
C07K 19/00
Applicants: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
경북대학교 산학협력단
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
한국과학기술연구원
Inventors: KIM, So Youn
김소연
KIM, Gwang-Seob
김광섭
SEO, Jun Young
서준영
KIM, In-San
김인산
Title: HUMAN-DERIVED FERRITIN MONOMER FRAGMENT AND FUSION POLYPEPTIDE USING SAME
Abstract:
The present invention relates to a human-derived ferritin monomer fragment and a fusion polypeptide using the same and, more specifically, to: a ferritin monomer fragment of which a portion of a fourth loop and a fifth helix, of a human-derived ferritin, are removed; and a fusion polypeptide in which a polypeptide or a protein is fused to an N-terminus or a C-terminus of the ferritin monomer fragment. The fusion polypeptide has very excellent production efficiency, forms a protein cage by self-assembly, thereby enabling encapsulation of active ingredients therein, and has a low steric hindrance effect due to the property of the three-dimensional structure thereof, thereby allowing the physiological activity of the polypeptide or the protein, fused to the N-terminus or the C-terminus, to be greatly exhibited, and thus can be useful in diagnosing diseases or developing therapeutic agents.