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|1. (WO2017039382) HUMAN-DERIVED FERRITIN MONOMER FRAGMENT AND FUSION POLYPEPTIDE USING SAME|
|Applicants:||KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
|Inventors:||KIM, So Youn
SEO, Jun Young
|Title:||HUMAN-DERIVED FERRITIN MONOMER FRAGMENT AND FUSION POLYPEPTIDE USING SAME|
The present invention relates to a human-derived ferritin monomer fragment and a fusion polypeptide using the same and, more specifically, to: a ferritin monomer fragment of which a portion of a fourth loop and a fifth helix, of a human-derived ferritin, are removed; and a fusion polypeptide in which a polypeptide or a protein is fused to an N-terminus or a C-terminus of the ferritin monomer fragment. The fusion polypeptide has very excellent production efficiency, forms a protein cage by self-assembly, thereby enabling encapsulation of active ingredients therein, and has a low steric hindrance effect due to the property of the three-dimensional structure thereof, thereby allowing the physiological activity of the polypeptide or the protein, fused to the N-terminus or the C-terminus, to be greatly exhibited, and thus can be useful in diagnosing diseases or developing therapeutic agents.