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1. (WO2017039359) COMPOSITION FOR DIAGNOSING INFECTIOUS DISEASES OR INFECTIOUS COMPLICATIONS BY USING TRYPTOPHANYL-TRNA SYNTHETASE AND METHOD FOR DETECTING DIAGNOSTIC MARKER

Pub. No.:    WO/2017/039359    International Application No.:    PCT/KR2016/009802
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: G01N 33/573
C12Q 1/68
C07K 16/40
Applicants: JW BIOSCIENCE
제이더블유바이오사이언스 주식회사
Inventors: KIM, Sunghoon
김성훈
JIN, Mi Rim
진미림
AHN, Young Ha
안영하
Title: COMPOSITION FOR DIAGNOSING INFECTIOUS DISEASES OR INFECTIOUS COMPLICATIONS BY USING TRYPTOPHANYL-TRNA SYNTHETASE AND METHOD FOR DETECTING DIAGNOSTIC MARKER
Abstract:
The present invention relates to a composition for diagnosing infectious diseases by using a tryptophanyl-tRNA synthetase (WRS) and a method for detecting a diagnostic marker and, more specifically, to: a composition for diagnosing infectious diseases, containing a preparation measuring the WRS protein or mRNA expression level; a diagnostic kit; a method for detecting the WRS for providing information required for the diagnosis of infectious diseases, and a method for determining the infectious disease mortality risk by using the WRS. According to the present invention, the WRS is increased only in infection-induced infectious diseases, differentiating non-infectious diseases therefrom, and is rapidly increased in the early stage of infection. In addition, the level of the WRS is closely correlated with the severity and prognosis of diseases or complications induced by infection. Therefore, the WRS can be used as a marker for more rapid and accurate diagnosis, in comparison to a conventional marker for infectious diseases or complications thereof.