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1. (WO2017039335) METHOD FOR MANUFACTURING HYALURONATE FIBERS BY USING MELT SPINNING AND HYALURONATE FIBERS MANUFACTURED THEREBY

Pub. No.:    WO/2017/039335    International Application No.:    PCT/KR2016/009748
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: D01F 9/00
D01D 5/08
A61K 31/728
A61B 17/06
A61L 27/20
Applicants: JINWOO BIO CO.,LTD.
(주)진우바이오
Inventors: KWEON, Dong Keon
권동건
PARK, Seung Hyeon
박승현
Title: METHOD FOR MANUFACTURING HYALURONATE FIBERS BY USING MELT SPINNING AND HYALURONATE FIBERS MANUFACTURED THEREBY
Abstract:
The present invention relates to hyaluronate fibers and, more specifically, to: hyaluronate fibers which can be used as a surgical suture, a filler for cosmetic surgery, a lifting thread, scaffold for tissue engineering, and the like; and a manufacturing method therefor. The method for manufacturing hyaluronate fibers by using melt spinning, comprises the steps of: (a) adjusting the water content of hyaluronate, having a weight-average molecular weight of 500-3,000 kDa, to 5-20%; (b) putting the hyaluronate of which the water content is adjusted in a melt spinning device, heating the same to 150-200°C, and performing high pressure spinning so as to manufacture hyaluronate fibers; and (c) dipping the hyaluronate fibers in an ethanol aqueous solution and hardening the surface thereof. The hyaluronate fibers of the present invention are manufactured with hyaluronate as the primary component, thereby having excellent safety and biocompatibility, and do not cause contamination by microorganisms, as opposed to conventional liquid hydrogel products, and are easy to manage and use, thereby being usable as various forms of preparations for repairing tissues. In addition, the hyaluronate fibers of the present invention are solid-form products, thereby having a very small volume in comparison to the concentration of the hyaluronate, such that the therapeutic effect thereof can be maximized by minimizing a patient's pain and discomfort during administration to the body.