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1. (WO2017039331) HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS

Pub. No.:    WO/2017/039331    International Application No.:    PCT/KR2016/009743
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: C07D 401/04
C07D 403/04
A61K 31/4439
A61K 31/497
Applicants: DONG-A SOCIO HOLDINGS CO., LTD.
Inventors: KIM, Myeong-Seop
KIM, Sumin
KIM, Jin Kwan
KIM, Hadong
RYU, Ki Moon
PARK, Seong Jin
PARK, Taesun
SHEEN, Joon-Ho
YOON, Taeyoung
JANG, Mi Yeon
Title: HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS
Abstract:
The present invention provides heterocyclic compounds, the stereoisomer thereof, the enantiomer thereof, or the pharmaceutically acceptable salt, which are capable of modulating the activity of Mer receptor tyrosine kinase (MERTK). This invention also provides pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The present invention is directed to MERTK inhibitory compounds with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to MERTK dysregulation.