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1. (WO2017038945) THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH ACCUMULATION OF ABNORMAL SUBSTANCES IN CELLS, BIOMARKER, DIAGNOSTIC AGENT, AND SCREENING METHOD

Pub. No.:    WO/2017/038945    International Application No.:    PCT/JP2016/075702
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: A61K 45/00
A61K 31/7105
A61K 31/713
A61K 48/00
A61P 1/04
A61P 3/10
A61P 21/00
A61P 21/04
A61P 25/00
A61P 25/14
A61P 25/16
A61P 25/28
A61P 27/02
A61P 43/00
Applicants: UNIVERSITY EDUCATIONAL FOUNDATION KYOTO SANGYO UNIVERSITY
学校法人京都産業大学
Inventors: YAMAMOTO Yohei
山本 洋平
NAGATA Kazuhiro
永田 和宏
NUKINA Nobuyuki
貫名 信行
MIYAZAKI Haruko
宮▲崎▼ 晴子
Title: THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH ACCUMULATION OF ABNORMAL SUBSTANCES IN CELLS, BIOMARKER, DIAGNOSTIC AGENT, AND SCREENING METHOD
Abstract:
Provided is a therapeutic agent for diseases associated with the accumulation of abnormal substances in cells which contains, as an active ingredient, a substance for suppressing the expression of ERdj8, or a substance for suppressing an autophagy activity suppression function which ERdj8 has. Further provided is a biomarker for detecting diseases associated with the accumulation of abnormal substances, which comprise ERdj8in, in cells. Further provided is a diagnostic agent for use in the detection of diseases associated with the accumulation of abnormal substances in cells, which includes substances which specifically bind to ERdj8. Further provided is a method for screening candidate substances for the therapeutic agent for diseases associated with the accumulation of abnormal substances in cells, having serve as an indicator (a) activity of ERdj8 for suppressing the autophagy activity suppression function, or (b) activity for suppressing the expression amount of ERdj8, which a substance to be tested has.