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1. (WO2017038939) METHOD FOR DETECTING PRECANCEROUS ORAL LESION

Pub. No.:    WO/2017/038939    International Application No.:    PCT/JP2016/075667
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: C12Q 1/68
G01N 33/50
C12N 15/09
Applicants: KAGOSHIMA UNIVERSITY
国立大学法人鹿児島大学
Inventors: HAMADA Tomofumi
▲濱▼田 倫史
Title: METHOD FOR DETECTING PRECANCEROUS ORAL LESION
Abstract:
Provided is a non-invasive method that enables the early detection, via large-scale screening, of a precancerous lesion that has a chance of developing oral cancer. This method, in which data for diagnosing a precancerous oral lesion in a patient is acquired by detecting the methylation of DNA in a gargled solution collected from the patient, is characterized in that said DNA is the DNA of a promoter region of the DNA of at least one of the following genes: RASSF1, DAPK1, CD44, BRCA2, FHIT, CDKN2A, HIC1, CASP8, RARβ, CDKN2B, CHFR, ATM, CDKN1B, BRCA1, and CADM1.